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In addition to genetic susceptibility to autoimmune syndromes, a specific trigger is often the cause. It can be: infections; certain foods (such as gluten - gluten); chemical impact; medicines; extreme physical stress; physical injury. APS-I is a rare childhood disorder occurring in children, endemic in some families, especially in Iran and Finland, affecting boys and girls. APS-II is more common than APS-I, affecting more women than men (3-4:1). As a rule, the disease is found in adults, the highest incidence is recorded after 50 years. Due to the increase in the number of autoimmune diseases in the population, the frequency of APS-II is steadily increasing.
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But the disease does not necessarily manifest itself clinically if the lesion of the gland is less than 80-90%. APS is more common in children, but often occurs in adulthood. The first signs indicating the presence of the disease are fatigue, cardiovascular, metabolic symptoms, impaired response to stress. Symptoms depend on the type of tenormin pills polyglandular syndrome.